What is Microbiome Labs MegaGenesis Probiotic

MegaGenesis™ was created to reintroduce a microbe from the past that’s missing—one isolated from a rich biodiverse gut microbiome. MegaGenesis™ contains the Limosilactobacillus reuteri PB-W1® strain isolated from a healthy Papua New Guinean adult. The PB-W1® strain’s phylogenetically unique characteristics differentiate it from other westernized L. reuteri strains. A high-fiber diet supports it, according to one clinical study. While we may not be able to turn back the clock on industrialization, we can reclaim and reintroduce missing microbial species!

Industrialization and the Human Gut Microbiome

Our non-industrialized ancestors followed a diet rich in plant-based foods that were seasonal, organic, and diversified. However, over the last 100 years, industrialization has changed the food supply and shifted dietary patterns. These changes result in a lack of accessible carbohydrates that specifically feed the microbiome, such as complex dietary fibers and oligosaccharides. Scientists have found that westernized dietary and environmental changes affect gut microbiomes and health. Modernization has changed the quantity and type of gut bacteria. Researchers suggest that certain species of intestinal bacteria may support long-term health.

Research studies have shown that ancestral populations today enjoy:

• Higher microbial diversity

• Production of microbial metabolites that support immune functions

• Resilient gut microbiomes

Relevant Discoveries from Non-Industrialized Communities

Papua New Guinea (PNG) individuals live a well-established, traditional, non-industrialized lifestyle characterized by a 10,000-year-old sustainable agriculture system. Their dietary pattern is rich in complex starches like taro, sweet potato, and plantain

A 2015 study assessed microbial patterns, species richness, and overall microbial diversity in fecal samples from two non-industrialized PNG communities and compared them to a United States cohort. The core bacterial phylum compromising the microbiome was similar in both groups. However, bacterial species and strains varied significantly. The PNG microbiomes showed a much higher number of overall bacterial species (alpha diversity), closely associated with stronger and more resilient gut microbiomes.

Studies show that less-industrialized societies have a greater bacterial alpha diversity. Indigenous populations eating high-fiber, plant-based diets, like PNG, have major differences in bacterial types. The PNG studies reveal high species richness and diversity, notably in Lactobacillus bacteria. Some of the Lactobacillus strains isolated from PNG individuals have been rarely seen in western societies since the 1960s. Notably, there have been significant discoveries of lost bacterial species

Dosing Instructions

Ages 3+ Take 1 capsule daily with or without a meal

If taking medication, pregnant, or breastfeeding please consult a licensed healthcare provider before taking this supplement. Vitamin supplements should not replace a balanced diet. Always read the label. Use as directed. If symptoms persist, talk to your health professional.

*These statements have not been evaluated by the Food & Drug Administration or TGA. These products are not intended to diagnose, treat, cure or prevent any disease. The information contained herein is for informational purposes only and does not establish a doctor-patient relationship.

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https://clinicaltrials.gov/ct2/show/NCT03501082